Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hand2  heart and neural crest derivatives expressed 2   (Synonyms: bHLHa26, dHAND, Ehand2, Hed, Thing2)
Results	Reference
1	J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48
1	J:220960 Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y, Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
1*	J:62028 Charite J, McFadden DG, Olson EN, The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70
1	J:61522 Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA, Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the sonic hedgehog pathway. Development. 2000 May;127(10):2133-42
1	J:159210 Galli A, Robay D, Osterwalder M, Bao X, Benazet JD, Tariq M, Paro R, Mackem S, Zeller R, Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
1	J:184018 Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y, Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
1	J:312493 Jhanwar S, Malkmus J, Stolte J, Romashkina O, Zuniga A, Zeller R, Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development. Nat Commun. 2021 Sep 28;12(1):5685
1	J:186421 Klaus A, Muller M, Schulz H, Saga Y, Martin JF, Birchmeier W, Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6
1	J:99350 Kmita M, Tarchini B, Zakany J, Logan M, Tabin CJ, Duboule D, Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature. 2005 Jun 23;435(7045):1113-6
1	J:321504 Lex RK, Zhou W, Ji Z, Falkenstein KN, Schuler KE, Windsor KE, Kim JD, Ji H, Vokes SA, GLI transcriptional repression is inert prior to Hedgehog pathway activation. Nat Commun. 2022 Feb 10;13(1):808
1*	J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
1*	J:284123 Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix DA, Schulz MH, Muller-McNicoll M, Dimmeler S, Grote P, The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev Cell. 2019 Sep 9;50(5):644-657.e8
1	J:77675 te Welscher P, Fernandez-Teran M, Ros MA, Zeller R, Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 2002 Feb 15;16(4):421-6
1*	J:49658 Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN , Srivastava D, A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug;125(16):3005-14
1	J:60342 Yamagishi H, Olson EN, Srivastava D, The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000 Feb;105(3):261-70
1	J:170604 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X, The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65
1	J:219584 Zhulyn O, Hui CC, Sufu and Kif7 in limb patterning and development. Dev Dyn. 2015 Mar;244(3):468-78
1	J:213417 Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC, A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28;29(2):241-9
1*	J:218166 Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC, Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan 15;397(2):191-202